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To view a copy of this licence, visit About this article Cite this article Fleishman, J.S., Kumar, S
Studies reveal that the active component extracted from Bupleurum, Sasycosaponin B2 (SSB2), significantly improves depressive symptoms by reducing levels of ROS and Fe 2+ in microglia, enhancing the transcription levels of GSH, SLC7A11, FTH, GPX4, and Nrf2, while downregulating ACSL4 and Tfr1 to inhibit lipid peroxidation and cellular ferroptosis
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