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The company recommends 500mcg once daily orally

Uses: In combination with pembrolizumab and platinum chemotherapy, for the initial treatment of patients with metastatic nonsquamous NSCLC, with no epidermal growth factor receptor (EGFR) or anaplastic lymphoma receptor tyrosine kinase (ALK) genomic tumor aberrations In combination with cisplatin, for the initial treatment of patients with locally advanced or metastatic, nonsquamous NSCLC As a single agent, for the maintenance treatment of patients with locally advanced or metastatic nonsquamous NSCLC whose disease has not progressed after 4 cycles of platinum-based first-line chemotherapy As a single agent, for the treatment of patients with recurrent, metastatic nonsquamous NSCLC after prior chemotherapy Usual Adult Dose for Malignant Pleural Mesothelioma 500 mg/m2 IV on Day 1 of each 21-day cycle until disease progression or unacceptable toxicity Use: In combination with cisplatin, for the initial treatment of patients with malignant pleural mesothelioma whose disease is unresectable or who are otherwise not candidates for curative surgery Renal Dose Adjustments CrCl 45 mL/min or greater: No adjustment recommended CrCl less than 45 mL/min: Not recommended If renal toxicity develops during therapy: This drug should be withheld until CrCl is 45 mL/min or greater

C.OkumuraY.FujioK.HuangT.et al (2022)

In the case of a specified area or medical topic determined appropriate by the Secretary for which a feasible and practical measure has not been endorsed, section 1899B(e)(2)(B) of the Act permits the Secretary to specify a measure that is not so endorsed, as long as due consideration is given to the measures that have been endorsed or adopted by a consensus organization identified by the Secretary