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This study demonstrated that ERT not only ameliorated structural deformities but also reduced oxidative stress and increased the gene expression of kidney cells in Fabry kidney organoids, which means that Fabry kidney organoids are useful tools for investigating the efficacy of ERT and will contribute to the development of new forms of ERT

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4e, f, the analysis of Bader charge and PDOS reveal that the Ru center in Ru-hydroxide, with a higher charge density, has a weaker interaction with the *OOH intermediate