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Gastrointestinal severity scale( r = 0.907), pain( r = 0.768), distention( r = 0.644), sucking sensation( r = 0.487), rumbling abdomen( r = 0.571), score of the general subscale( r = 0.834), nausea, vomiting ( r = 0.641), heartburn( r = 0.717), acid regurgitation( r = 0.729), score of the upper GIT subscale( r = 0.780), increased flatus( r = 0.098), decreased passage of stool( r = 0.313), increased passage of stool( r = 0.273), loose stool( r = 0.318), hard stool( r = 0.412), urgency of defecation( r = 0.297), sensation of incomplete defecation( r = 0.366), and score of lower GIT subscale( r = 0.648) as shown in Table 5

Experimental findings in Agaricus bisporus have demonstrated that cultivation conditions associated with increased oxidative loadsuch as high oxygen supply or the third flush of fruitingare correlated with elevated EGT levels in fruiting bodies

While previous reviews have addressed micronutrient roles in thyroid dysfunction or cardiovascular risk independently, this review offers a novel integrative approach by linking nutrient status, sex-specific effects, and autoimmune mechanisms into a unified framework