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J Korean Med Sci 29(7):965972 Sato Y et al (2013) Relationship between metformin use, vitamin B12 deficiency, hyperhomocysteinemia and vascular complications in patients with type 2 diabetes
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PMID 8060829

The activation of SIRT1 through increased NAD+ availability improves how cells respond to insulin, facilitating better glucose uptake and utilization

Manufacturers and providers are experimenting with adding compounds such as vitamin B12 to semaglutide
