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New therapies, such as biological agents, herbal therapies, and microecologics and FMT, have become significant research hotspots and are discussed in the following sections of this article

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Currently, retatrutide is in phase 3 clinical trials to determine its long-term safety and efficacy for weight loss in obese and overweight individuals, knee osteoarthritis, and obstructive sleep apnea

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conversely, transfection with a miR-181b inhibitor was confirmed to inhibit chondrocyte ferroptosis by increasing SLC7A11 and GPX4 expression levels (Wang D