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For the administration of medications via ophthalmic, oral, topical, parenteral, pulmonary and transdermal routes, NLCs have emerged as a viable carrier system [162, 163]

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Chamcheu JC, Siddiqui IA, Adhami VM, Esnault S, Bharali DJ, Babatunde AS, Adame S, Massey RJ, Wood GS, Longley BJ, Mousa SA, Mukhtar H (2018) Chitosan-based nanoformulated (-)-epigallocatechin-3-gallate (EGCG) modulates human keratinocyte-induced responses and alleviates imiquimod-induced murine psoriasiform dermatitis

This promotes the production of pro-inflammatory cytokines such as TNF-, IL-1 and IL-6

A., Gimeno-Santos, E., Cates, C