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In the CT-like conformation, the bypass motif becomes unstructured, and residues (S21-P28) are not well resolved, suggesting this flexible segment is exposed to the solvent environment

[DOI] [PubMed] [Google Scholar] 109.Peng L., Zheng H.Y., Dai Y

A four amino acid deletion polymorphism in the third intracellular loop of the human alpha 2C-adrenergic receptor confers impaired coupling to multiple effectors

In contrast, the dipeptide Asp-Arg, corresponding to the N-terminal dipeptide of angiotensin II (Table S1), exhibited no inhibitory activity against the hydrolysis of Gly-Phe-pNA by DAP BII (WT) (Table S5)

Some of the limitations of this study included the sample size, length of observation, and a variety of tumor sources