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Not great for an entire PO regimen.) The IV protocol is a 20 hour treatment: Loading Dose: 150 mg/kg (max: 15 g) infused over 1 hour Second Dose: 50 mg/kg (max: 5 g) infused over 4 hours Third Dose: 100 mg/kg (max: 10 g) infused over 16 hours The PO protocol is a 72 hour treatment (rotten eggs for 72 hours!!): Loading Dose: 140 mg/kg Maintenance Dose: 70 mg/kg every 4 hours for a total of 18 doses NAC is typically the first-line option for the treatment of acetaminophen toxicity