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Dysbiosis and impaired barrier function increase the translocation of microbe-associated molecular patterns, such as LPS, which can induce a systemic inflammatory state and the release of cytokines such as IL-6 and TNF- (101)

Images were collected of 135.21 135.21 m size with a pixel size of 26.4 26.4nm using NIS Elements software

doi: 10.1016/j.mtbio.2025.101896 401 HouCXiaoJWangYPanXLiuKLuKet al

For example, the nuclear receptors CAR and PXR, as cardiovascular metabolic regulators, have garnered attention for their roles in lipid and glucose homeostasis, blood pressure regulation, and atherosclerosis ( 5.2 Current research challenges and limitations Although the sex hormone-ferroptosis regulatory axis offers a promising theoretical framework for understanding sex differences in AS, we must acknowledge the significan challenges and inherent limitations of current research

It is important to note that not all tryptophan metabolites exhibit pro-inflammatory effects
