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Because of the high heterogeneity of tumors, according to Darwinian evolutionary principles, drug-resistant mutants are selected, or subpopulations of primary resistant tumor stem cells in the dormant phase can cause tumors to regrow or spread

17 These costs were limited to those for extra anti-infective treatments needed (i.e., 1114.87), rather than effects of new infections on length of hospital stay or mortality rates, as length of stay and mortality rates were already included in the model as clinical outcomes