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While early safety data appear favorable, the potential for proangiogenic activity to influence oncogenic processes underscores the importance of comprehensive cancer pre-screening prior to therapeutic use

GPx4 protein was downloaded from the PDB database ( with the ID of 2OBI

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LEfSe is known to reduce false positives and can highlight biological consistency across subclasses, while the KruskalWallis test used alone can achieve a lower false-negative rate compared to LEfSe 38