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Nature Rev Drug Discovery 7(1): 21-39.

Martina V, Masha A, Gigliardi VR, Brocato L, Manzato E, Berchio A, Massarenti P, Settanni F, Della Casa L, Bergamini S, Iannone A

Visual inspection is your first line of defense

Timing and Consistency: When and how the dose is administered can also play a role

TRPM2 was shown to be activated by hypoxia-induced ADP-ribose and oxidative stress, common events in DR pathogenesis, and its blockage restored pro-inflammatory cytokines (TNF- and IL-1) and ROS levels (zkaya et al., 2021)
