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Prparation : Cuir chevelu propre et sec

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The eluate was either analyzed by SDS-PAGE or diluted 1:100 in chromatography buffer A for a subsequent enzymatic assay

Two other studies demonstrated that MAPK pathway inhibitors in combination with HDACi suppressed cAMP mediated resistance in melanoma cells [109] and that pre-treatment of platinum drug resistant ovarian cancer cells with HDACi and methylation inhibitors sensitized these cells to cisplatin-mediated cell death [110]