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The conservative 1mg starting dose allows assessment of individual tolerance before increasing

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doi: 10.1016/j.bbadis.2018.12.005

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However, research shows that all forms of B12 follow the same route of absorption, including being bound to and released from the same transport and other proteins and so researchers believe that supplementing with adenosylcobalamin or methylcobalamin is unlikely to offer an advantage over cyanocobalamin in healthy people (Obeid et al., 2015)