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In conclusion, targeting ferroptosis offers a promising new avenue to overcome tumor drug resistance, and through continued mechanistic investigation, technological innovation, and clinical translation, ferroptosis-based therapies are poised to become a central pillar in future cancer treatment paradigms

The unique microenvironment of the renal medulla promotes hemoglobin polymerization and subsequent vaso-occlusion, leading to ischemic damage of the renal papillae

MOTS-c acts as a mitokine, a hormone-like signal that reports on the health status of the mitochondria and orchestrates a coordinated systemic response

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In rare cases in which the catchment area population values were not available, non-weighted means were used in the aggregation