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Indeed, it may be difficult or even impossible to determine whether, in terms of oxidative stress, modern factors such as pharmaceuticals, pollutants from the combustion of fossil fuels, and other factors from industrial processes outweigh more historical factors such as smoke from cooking fires and naturally occurring toxins from food obtained by hunting and gathering

Oxidative stress is one of the important mechanisms for cell damage and disease occurrence

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Br J Dermatol 152(6):10981107 Timar KK, Pasch MC, van den Bosch NH, Jarva H, Junnikkala S, Meri S et al (2006) Human keratinocytes produce the complement inhibitor factor H: synthesis is regulated by interferon-gamma