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Regular or heavy alcohol consumption can interfere with the body's ability to absorb Vitamin B12 from the gut, making the supplement less effective

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Rather than raising NAD+ systemically (as NMN or NR supplementation does), NNMT inhibition preserves NAD+ specifically in the tissue where metabolic dysfunction is most pronounced a precision approach that appeals to researchers studying tissue-specific metabolic regulation

It might make you feel more alert, but then you might drink more alcohol and become more intoxicated