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In many cases, individuals may transition to a maintenance phase where injections are administered less frequently, such as once every two weeks or once a month

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Administration of 200 mg/kg silymarin also reduced the rotational behavior caused by 6-hydroxydopamine (6-OHDA) in hemi-parkinsonian rats and the substantia nigra pars compacta neurons were protected against its toxicity, suggesting a dose-dependently neuroprotection effect of silymarin against 6-OHDA toxicity, through oxidative stress decline and by means of an estrogenic pathway (52)