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However, many open questions remain and the results of various clinical trials testing the effectiveness of anti-stress therapies are inconclusive, which hinders a proper preclinical to clinical transition and their inclusion into current medical guidelines in oncology
Preclinical and in vitro studies have consistently demonstrated its ability to stimulate collagen, elastin, and glycosaminoglycan synthesis in fibroblast cell cultures

(2011c)

Specific abnormal clinical presentations require targeted interventions to mitigate their impact on daily functioning

Mnguez-Alarcn L, Williams PL, Souter I, et al