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Nesse estudo, o GHK-Cu reduziu produo de espcies reativas de oxignio, aumentou atividade de superxido dismutase, diminuiu TNF-alfa e IL-6, suprimiu vias inflamatrias como NF-kB p65 e p38 MAPK, alm de atenuar alteraes histolgicas pulmonares em modelo animal

Ponesimod, another S1P analogue exclusively binding to S1PR1, showed high tropism to astrocytes, causing a long-term antagonism to receptor activity
