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You S, McIntyre G, Passioura T

doi: 10.3389/fphar.2026.1746683 Received 14 November 2025 Revised 21 January 2026 Accepted 29 January 2026 Published 11 February 2026 Volume 17 - 2026 Edited by Muhammad Nabeel Ghayur, University of Pikeville, United States Reviewed by Hctor E

Lactate Dehydrogenase (LDH) Assay The relative amounts of LDH released into the media (conducted in triplicates for each group) were determined using CytoTox-ONE Homogeneous Membrane Integrity Assay kit Cat.#G7892 (Promega, USA) according to the manufacturers instructions

Mutations in these epigenetic regulators can lead to the hyperactivation of WNT signaling that alters dendritic and spinal morphology to underlie ASD-like behaviors, including circuit dysfunction and social deficits