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Yang et al., 2011)

7.3 Development of combined intervention strategies The revised section now discusses the potential of combined therapeutic approaches, such as the co-administration of natural bioactive compounds with probiotics or prebiotics, to synergistically regulate gut microbiota composition, restore intestinal barrier integrity, and reduce hepatic oxidative stress and inflammation

Although the pathophysiologic functions of PGD 2 and PGE 2 in FCMD remain unclear, certain predictions can be made based on previous studies on other muscular dystrophies including DMD 11,24

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However, long-term mucolytics exposure is associated with inflammation, metabolic syndrome and increased microbial proximity 205