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doi: 10.1016/S0140-6736(96)07642-8
They reported the effect to be triggered by a single active constituent or by the combined action of many agents found in the extract that contributes to hypotensive and vasorelaxation activities (Chiou et al., 2000)
This later phase is characterized by emerging motor fluctuations, where plasma levodopa levels frequently spike above the therapeutic window into peak-dose dyskinesia or drop below it into 'OFF' periods (wearing-off)
TrkB, tyrosine kinase receptor B
