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In the vessels, reactive species can be produced by nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, xanthine oxidase, lipoxygenases, cyclooxygenase, myeloperoxidases, nitric oxide synthase, and uncoupled endothelial nitric oxide synthetase, dysfunctional mitochondria as well as metal ion catalysis (Kattoor et al., 2017

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