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44,45 These features are frequently accompanied by the downregulation of ezrin, 46 a cytoskeletal protein critical for maintaining astrocytic leaflets and synaptic coverage

Being an acetylated form of the amino acid L-cysteine allows NAC to be readily absorbed (whereas normal L-cysteine tends to be significantly degraded by first-pass metabolism)

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10.3390/ijms242015240 [DOI] [PMC free article] [PubMed] [Google Scholar] Andrs CMC, de la Prez JM, Andrs Juan C, Plou FJ, Prez-Lebea E (2023b) Chemistry of hydrogen sulfide-pathological and physiological functions in mammalian cells

As an electron donor, this evolutionary old molecule stabilises free radicals and thus participates in the preservation of a cellular redox state (Kranner et al