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This is often due to increased osteoclastic activity and diminished osteoblast activity, as observed in age-related and secondary osteoporosis or in inflammation-induced (e.g., in rheumatoid arthritis) or cancer-induced bone loss (reviewed in [2])

Other than that, its very important for the proper function of our brain

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Consequently, the forms of polyphenols present in human blood and tissues differ from those in foods, complicating the identification of all metabolites and the assessment of their biological activity