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The mean fluorescence intensity for ROS-responsive hydrogel with monomer copper peptides M-CuP (G/M-CuP) and G/D-CuP groups decreased by 71% and 63%, respectively, in comparison to the NC group (Supplementary Fig

L-012 ( b , c ) and fluorescein-boronate (Fl-B) ( d , e ) were used for detection

Atanackovic et al

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Structural Features: Stability Optimization: Lipid chain conjugation extends in-vivo residence time (fatty acid modified peptide technology) Disulfide bridge (Cys-Cys) stabilizes 3D conformation Amino Acid Sequence: Pyr-Lys-Cys-Asn-Thr-Ala-Thr-Cys-Ala-Thr-Gln-Arg-Leu-Ala-Glu-Phe-Leu-Arg-His-Ser-Ser-Asn-Asn-Phe-Gly-Pro-Ile-Leu-Pro-Pro-Thr-Asn-Val-Gly-Ser-Asn-Thr-Pro-OH (Disulfide bond: Cys-Cys) Reviews of Cagrilintide Key Properties of Cagrilintide 1