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Milosavljevic V, Jamroz E, Gagic M et al (2020) Encapsulation of doxorubicin in furcellaran/chitosan nanocapsules by layer-by-layer technique for selectively controlled drug delivery

Thiol isomerases like protein disulfide isomerase (PDI) are thought to catalyze these redox changes

This inhibition renders GPX4 unable to perform its protective function due to shortage of its required co-substrate GSH, making chondrocytes more susceptible to ferroptosis

10.1242/dev.067587 124 SandriM.BarberiL.BijlsmaA.BlaauwB.DyarK.MilanG.et al

Further doseresponse and steady-state administration studies will be required to optimize the dosing schedule for future trials to evaluate therapeutic efficacy