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Oral Shipment of Drug Barriers and Advancements Discover the challenges and advancements in the oral delivery of peptide drugs

In vitro permeation and in vivo adsorption testing confirmed that RGD-GHK achieved a high local concentration in the skin layer, initiating peptide effects and facilitating in vivo wound healing, while maintaining excellent biocompatibility

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Interestingly, these effects were more pronounced in the high-dose APLA group compared to PLA, suggesting dose- and type-dependent neurotoxicity (Qian et al., 2025)

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