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[PubMed] This combination provides support from multiple angles without requiring multiple injections

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The complex is further stabilized by a set of apparently hydrogen bonds formed between the backbone amide of V569 of ASXL1 EBM and the side chain carboxyl group of E657 of BRD4 ET and between the backbone amide of L576 of ASXL1 EBM and the backbone carbonyl of D650 of BRD4 ET

In the regulation of amino acid homeostasis, the general control non-derepressible 2 (GCN2)-activating transcription factor 4 (ATF4) and mammalian target of rapamycin complex 1 (mTORC1) play key roles

Sharma et al., 2008b