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It has also been shown that the short-chain FA butyrate, a bacterial metabolite, inhibits histone acetylation on murine BMDCs and induces Treg differentiation (62)

10.1007/978-3-030-51856-1_4 Anim

Hypoxia-triggered cleavable conjugations Hypoxia is condition refers to the absence of enough oxygen level in cells and tissues that is required to sustain biological functions

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Thus, the development of more stable ferroptosis inhibitors that are safe to use in human disease is an unmet clinical need