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In vivo, transgenic mice overexpressing human WASF3 displayed significantly reduced exercise capacity and higher blood lactate levels compared to wild-type littermates, consistent with decreased oxidative metabolic capacity (115)

LeBleu VS, OConnell JT, Gonzalez Herrera KN, Wikman H, Pantel K, Haigis MC, et al

Blood 96(2):393-7, 2000

Even moderate changes in intracellular glutathione levels can profoundly impact lymphocyte function

Brightening happens when the barrier is healthy, not when its over-exfoliated
