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Reconstitution: 3.0 mL bacteriostatic water per 600 mg vial gives 200 mg/mL (1 unit = 2 mg)

Integrative analysis of drug response and clinical outcome in acute myeloid leukemia

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The state of chromatin is key in regulating gene expression and it is driven by two types of PTMs: (1) acetylation of lysine at the histone tail resulting in the activation of transcription and (2) methylation of lysine at the histone tail resulting in activation or repression of transcription depending on its position on the histone tail ( Despite a lack of knowledge regarding the exact mechanistic relationship between EDCs and epigenetic signatures, proposed mechanisms to date can be divided into two categories: gene-specific action and global action (Kouzmenko et al., 2010