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Gclc f/f mice were generated as described 30 and crossed with the Rosa26-CreERT2 mouse strain (Jackson Labs, #008463) or Nrf2 f/f mouse strain (Jackson Labs, #025433)

and lysine 6, lysine 12, and lysine 16 of histone H4 (H4K6, H4K12, and H4K16) ( Non-Histones SIRT1-driven deacetylation of multiple non-histone proteins has been shown to impact pathophysiological processes such as cell differentiation ( Regulation of SIRT1 Expression SIRT1 expression is subject to many layers of regulation, including at the transcriptional and post-transcriptional ( Table 1 and Figure 3 )

Geeson, Michael B

Czajkowski, M

[DOI] [PubMed] [Google Scholar] 5.Hodgman MJ, Garrard AR