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Post-Exertional Malaise (PEM): By quenching the massive explosion of reactive oxygen species (ROS) that occurs during physical or cognitive exertion, NAC helps protect mitochondria from the structural damage that leads to debilitating crashes

For example, the precise cell of origin for both OS and ES is still unclear and highly debated (148), and the timing of genetic and signaling events during development which govern malignant transformation are not well understood

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Activation of these genes enhances the cells ability to detoxify ROS and maintain redox homeostasis (Ngo and Duennwald 2022)

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