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Oxidative stress is the disturbance in the balance between the generation of free radicals, such as reactive oxygen species (ROS) and reactive nitrogen species (RNS), and antioxidant defenses, and can cause oxidative damage to diverse cellular components, such as membranes, proteins, and DNA

N.FlemingA.Devada,S.RanvirR.SundarR

Hmgb1 regulates ferroptosis through nrf2 pathway in mesangial cells in response to high glucose

however, this finding has not been followed up by intervention trials in humans

The main methodological points associated with case-control studies are the accuracy of the outcome, estimates of exposure, statistical power, confounding, and selection bias