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Although such a modulation of the action potential might be deemed to have minimal effects on the contractile function of cardiac cells, it is evident that TMAO is transiently limiting the amplitude of contraction as the washout of TMAO reverses the dampening of contractions (Figure 8)

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Another animal study showed that inhibition of TMAO formation can upregulate the host hepatic bile acid synthetic enzyme CYP7A1 and alter the expression of hepatic genes critical for bile acid feedback regulation, thus preventing diet-driven hepatic cholesterol accumulation (Pathak et al., 2020)

doi: 10.1016/j.rmr.2020.11.007

Valproate toxicity and ornithine carbamoyltransferase deficiency
