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Hope JH
A cyclical model of MDS pathogenesis and progression, including both genomic and immunological aspects, is shown in Figure 2
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Interestingly, recent studies indicate that lipopolysaccharide-stimulated macrophages also use the GABA shunt to generate succinate, which activates the transcription factor HIF-1 to enhance the production of the cytokine interleukin-1 for innate immunity
Nagana Gowda GA, Lusk JA, Pascua V
