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Looking ahead, the therapeutic potential of modulating CCK signaling warrants systematic investigation notably through the use of CCK-B receptor antagonists such as YM022 [48] and L365,260 [49]

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Bipolar depression treatment has limited evidence, although lots of drugs have been proposed as treatment options with similar efficacy but varying tolerability, such as lamotrigine, fluoxetine or antipsychotics as quetiapine or olanzapine, among others [236238]

According to the NIH Office of Dietary Supplements, B12 is essential for red blood cell formation, neurological function, and DNA synthesis