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Description
If the homeostatic balance is not restored after UPR induction, i.e., if acute UPR remains active for a prolonged time, the cell undergoes apoptosis and the UPR becomes chronically activated

(1972) J

MDM2, a major E3 ubiquitin-protein ligase, is an oncoprotein overexpressed in many human cancers (Wade et al., 2013

10.1016/j.neuron.2014.01.013 118 FreischmidtA.WielandT.RichterB.RufW.SchaefferV.MullerK.et al
The results showed a noticeable reduction in odor, decreased use of pain medication, tumor remission, and a desmoplastic reaction in connective tissue [468]
