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Description
PLGA, poly(lactic-co-glycolic acid
In ovarian cancer, tumor cell-derived exosomes carrying CMTM4 are taken up by macrophages, promoting TGF-1 and CXCL12 secretion via NF-B pathway activation and enhancing ICAM1/CD206-mediated M2 polarization, thereby reducing the efficacy of PD-1 inhibitors (203)
Such plant-derived active compounds enhance NO bioavailability directly by upregulating eNOS expression and activity via phosphorylation cascades involving PI3K/Akt signaling, thereby facilitating sustained NO production
At the same time, collagen stimulation and regenerative activity initiated by it may continue long after administration
74 OremlandR
