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COMT o-methylates catechol oestrogen metabolites and mediates their detoxification, and it is plausible that the activity of this enzyme is inhibited by the accumulation of the cysteine precursor homocysteine

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In addition, compared with that of the control (nave) group, the mRNA level of COLXA1 , a marker of hypertrophic chondrocytes, was significantly increased in GSH-low hES-MSCs but was decreased in GSH-high hES-MSCs (Fig

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Wu RM, Chen RC, Chiueh CC (2000) Effect of MAO-B inhibitors on MPP+ toxicity in Vivo
