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Several factors contribute to this regulation: Allosteric regulation by SAM : SAM serves as an allosteric activator of cystathionine -synthase (CBS), promoting the transsulfuration pathway when SAM levels are elevated

Bull Natl Res Cent 2024;48:100
Titration is key: Gradual dose escalation maximizes tolerability

Hall, M

Of course, theres immune suppression both from tick-borne diseases and from long COVID
