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Imaging studies of the brains of people with MCS show that TRPV1 and TRPA1 are overly sensitized.[ref] TRPV1 senses volatile compounds such as toluene, styrene, benzene, ethylbenzene, acetone, diethyl ether, hexane, heptane, cyclohexane, and formaldehyde

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Consequently, the authors established a cumulative methylation index (CMI), which was proposed as a potential biomarker for CRC diagnosis [274]