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Higher doses can stall the same process or even tip into toxicity over longer exposures, where free copper drifting loose from the complex starts driving oxidative damage

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VEGF is the primary driver of angiogenesis, the process by which new blood vessels form from existing ones

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Therefore, an effective release system must ensure that normal concentrations of ROS do not trigger the release of therapeutic drugs while allowing for drug release or enhancing the ability of materials to regulate ROS under pathological conditions [338]