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However, vitamin B 12 deficiency does not generally develop until after at least two-to-three years of continuous therapy (137-139)

The following have also been described: hypotonia, muscle weakness, lack of response to stimuli, delayed speech development, lack of interaction with people, involuntary movements, hyperpigmentation, enlargement of the liver and spleen, and low bone mineral density

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The endocannabinoid system is involved in a wide range of physiological processes, including digestion