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4.1 Pharmacokinetic and pharmacodynamic considerations of antioxidant supplementation in AMS As mentioned above, oxidative stress has been proposed as a key contributor to the pathophysiology of AMS, driven by hypobaric hypoxiainduced mitochondrial dysfunction, increased ROS generation, endothelial activation, and neurovascular dysregulation

All data for this manuscript are included in the paper and raw data are available for review upon request

The brightening is subtle at first but becomes more noticeable with consistent use

Together, these findings point to an exciting new frontier one where preserving energy transfer may be as vital as correcting mechanics in inherited hypercontractile cardiomyopathies
