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Acknowledgements The authors are also grateful to the staff of the Institutes of Advanced Technology, Department of Chemistry UPM for their help in this research, Institute of Bioscience (IBS/UPM) for technical assistance

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Clinical Update 9/02/2021 Myocarditis Fatalities How often has vaccine-related myocarditis led to fatalities among young people

3-Hydroxy-3-methylglutaryl-CoA synthase 2 (HMGCS2), the rate-limiting enzyme of ketogenesis, is hypersuccinylated in the absence of SIRT5, but this modification of HMGCS2 inhibits its activity and reduces ketone body production (Rardin et al., 2013)

Stanley SA, Barczak AK, Silvis MR, Luo SS, Sogi K, Vokes M, Bray MA, Carpenter AE, Moore CB, Siddiqi N, et al