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If you have digestive problems, it would be difficult for you to absorb the vitamin even if you consume foods high in Vitamin B12

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The clinical signs and symptoms of cobalamin-related remethylation disorders may vary considerably and affect multiple organ systems, most prominently the nervous system and the bone marrow

Comparing the effect of the combination of vitamins B1, B6, and B12 on cell maturation to the individual B vitamin treatments, the combination was 2.88-fold more effective in supporting cell maturation than B12 treatment, 50.90-fold more effective than B6 treatment, and 14.31-fold more effective than B1 treatment